7kfy

X-ray diffraction
2.16Å resolution

Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-F10 Fab)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike protein S1 Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 25.47 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
heavy chain of human antibody C1A-F10 Fab Chain: H
Molecule details ›
Chain: H
Length: 225 amino acids
Theoretical weight: 23.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
light chain of human antibody C1A-F10 Fab Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2221
Unit cell:
a: 85.74Å b: 146.801Å c: 144.593Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.249
Expression system: Homo sapiens