› 7ke7

Electron Microscopy
3.32Å resolution

SARS-CoV-2 D614G 3-RBD-down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G Sub-Classification)

Released:
DOI: 10.2210/pdb7ke7/pdb
PDB 7ke7 coloured by chain and viewed from the front.
PDB 7ke7 coloured by chain and viewed from the side.
PDB 7ke7 coloured by chain and viewed from the top.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Manne K, Stalls V, Kopp MF, Henderson R, Edwards RJ, Haynes BF, Acharya P
Cell Rep 34 108630 (2021)
PMID: 33417835
Related structures: EMD-22833

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.38 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 33 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.32Å
Relevant EMDB volumes: EMD-22833
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Cardiovascular protective properties of oxytocin against COVID-19.
Wang et al. (2021)
1 more