7k8y

Electron Microscopy
4.4Å resolution

Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C121 (State 2)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: B, D, E
Molecule details ›
Chains: B, D, E
Length: 1259 amino acids
Theoretical weight: 139.79 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1213; Coverage: 95%)
Gene names: 2, S
Sequence domains:
C121 Fab Heavy chain Chain: G
Molecule details ›
Chain: G
Length: 241 amino acids
Theoretical weight: 25.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
C121 Fab Light chain Chain: I
Molecule details ›
Chain: I
Length: 216 amino acids
Theoretical weight: 22.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-22735
Expression system: Homo sapiens