› 7k8y

Electron Microscopy
4.4Å resolution

Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C121 (State 2)

Released:
DOI: 10.2210/pdb7k8y/pdb
PDB 7k8y coloured by chain and viewed from the front.
PDB 7k8y coloured by chain and viewed from the side.
PDB 7k8y coloured by chain and viewed from the top.
Source organisms:
Entry authors: Abernathy ME, Barnes CO, Bjorkman PJ
Related structures: EMD-22735

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: B, D, E
Molecule details ›
Chains: B, D, E
Length: 1259 amino acids
Theoretical weight: 139.79 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1213; Coverage: 95%)
Gene names: 2, S
Sequence domains:
C121 Fab Heavy chain Chain: G
Molecule details ›
Chain: G
Length: 241 amino acids
Theoretical weight: 25.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
C121 Fab Light chain Chain: I
Molecule details ›
Chain: I
Length: 216 amino acids
Theoretical weight: 22.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 23 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-22735
Expression system: Homo sapiens

Quick links

Citations

72 review citations

A structural view of the SARS-CoV-2 virus and its assembly.
Hardenbrook et al. (2022)
71 more