7k8w

Electron Microscopy
3.6Å resolution

Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C119

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein Chains: A, B, G
Molecule details ›
Chains: A, B, G
Length: 1259 amino acids
Theoretical weight: 139.79 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1213; Coverage: 95%)
Gene names: 2, S
Sequence domains:
C119 Fab Heavy Chain Chains: H, N
Molecule details ›
Chains: H, N
Length: 239 amino acids
Theoretical weight: 25.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
C119 Fab Light Chain Chains: L, S
Molecule details ›
Chains: L, S
Length: 217 amino acids
Theoretical weight: 22.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-22733
Expression system: Homo sapiens