7k0j

Electron Microscopy
3.1Å resolution

Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa protomer

Released:

Function and Biology Details

Reaction catalysed:
Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2)
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Serine palmitoyltransferase 1 Chain: A
Molecule details ›
Chain: A
Length: 473 amino acids
Theoretical weight: 52.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15269 (Residues: 1-473; Coverage: 100%)
Gene names: LCB1, SPTLC1
Sequence domains: Aminotransferase class I and II
Serine palmitoyltransferase 2 Chain: B
Molecule details ›
Chain: B
Length: 562 amino acids
Theoretical weight: 63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15270 (Residues: 1-562; Coverage: 100%)
Gene names: KIAA0526, LCB2, SPTLC2
Sequence domains: Aminotransferase class I and II
Serine palmitoyltransferase small subunit A Chain: C
Molecule details ›
Chain: C
Length: 71 amino acids
Theoretical weight: 8.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q969W0 (Residues: 1-71; Coverage: 100%)
Gene names: C14orf147, SPTSSA, SSSPTA
Sequence domains: Small subunit of serine palmitoyltransferase-like

Ligands and Environments


Cofactor: Ligand PLP 1 x PLP
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-22599
Expression system: Homo sapiens