› 7jzk

X-ray diffraction
2.46Å resolution

Crystal structure of LAIR1 ectodomain (from MGD21) in complex with Plasmodium RIFIN (PF3D7_0401300) V2 domain

Released:
DOI: 10.2210/pdb7jzk/pdb
PDB entry 7jzk coloured by chain, front view.
PDB entry 7jzk coloured by chain, side view.
PDB entry 7jzk coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
Xu K, Wang Y, Shen CH, Chen Y, Zhang B, Liu K, Tsybovsky Y, Wang S, Farney SK, Gorman J, Stephens T, Verardi R, Yang Y, Zhou T, Chuang GY, Lanzavecchia A, Piccoli L, Kwong PD
Nat Commun 12 4226 (2021)
PMID: 34244481

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105588 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
LAIR1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 105 amino acids
Theoretical weight: 11.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A6B9UEV8 (Residues: 1-104; Coverage: 89%)
Sequence domains: Immunoglobulin domain
Rifin Chains: B, D
Molecule details ›
Chains: B, D
Length: 151 amino acids
Theoretical weight: 15.73 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8I211 (Residues: 174-324; Coverage: 42%)
Gene name: PF3D7_0401300
Sequence domains: Rifin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 87.118Å b: 95.839Å c: 71.828Å
α: 90° β: 103.97° γ: 90°
R-values:
R R work R free
0.225 0.223 0.275
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

LAIR1 drives glioma progression by nuclear focal adhesion kinase dependent expressions of cyclin D1 and immunosuppressive chemokines/cytokines.
Wei et al. (2023)

1 mention without citation

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
Xu et al. (2021)