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Crystal structure of LAIR1 ectodomain (from MGD21) in complex with Plasmodium RIFIN (PF3D7_1040300) V2 domain

X-ray diffraction
2.707Å resolution
PDB entry 7jzi coloured by chain, front view.
PDB entry 7jzi coloured by chain, side view.
PDB entry 7jzi coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: LAIR1 and Rifin
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Multimeric state: hetero dimer
Accessible surface area: 11721.69 Å2
Buried surface area: 1998.06 Å2
Dissociation area: 939.73 Å2
Dissociation energy (ΔGdiss): 7.15 kcal/mol
Dissociation entropy (TΔSdiss): 10.93 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-105589
Assembly 2
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Assembly Name: LAIR1 and Rifin
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Multimeric state: hetero dimer
Accessible surface area: 12275.15 Å2
Buried surface area: 2046.91 Å2
Dissociation area: 967.3 Å2
Dissociation energy (ΔGdiss): 8.78 kcal/mol
Dissociation entropy (TΔSdiss): 11.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-105589

Macromolecules

LAIR1
Chains: A, C
Length: 98 amino acids
Theoretical weight: 11.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A6B9UEV8 (Residues: 1-97; Coverage: 83%)
Pfam: Immunoglobulin domain
InterPro:
LAIR1 in PDB entry 7jzi, assembly 1, front view.
LAIR1 in PDB entry 7jzi, assembly 1, side view.
LAIR1 in PDB entry 7jzi, assembly 1, top view.
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Rifin
Chains: B, D
Length: 145 amino acids
Theoretical weight: 15.13 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8IJ06 (Residues: 184-328; Coverage: 41%)
Gene name: PF3D7_1040300
Pfam: Rifin
InterPro: Variant surface antigen Rifin
Rifin in PDB entry 7jzi, assembly 1, front view.
Rifin in PDB entry 7jzi, assembly 1, side view.
Rifin in PDB entry 7jzi, assembly 1, top view.
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