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Crystal structure of PTEN with a tetra-phosphorylated tail (4p-crPTEN-13sp-T2, SDTTDSDPENEG)

Source organism: Homo sapiens
Biochemical function: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
Biological process: phosphatidylinositol dephosphorylation
Cellular component: not assigned

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EC 3.1.3.67: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

Reaction catalysed:
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate
Systematic name:
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase
Alternative Name(s):
  • MMAC1
  • PTEN
  • Phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase

EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

EC 3.1.3.16: Protein-serine/threonine phosphatase

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • Aspergillus awamori acid protein phosphatase
  • BCKDH phosphatase
  • Branched-chain alpha-keto acid dehydrogenase phosphatase
  • Calcineurin
  • Casein phosphatase
  • HMG-CoA reductase phosphatase
  • Phosphatase 2A
  • Phosphatase 2B
  • Phosphatase C-II
  • Phosphatase H-II
  • Phosphatase I
  • Phosphatase IB
  • Phosphatase II
  • Phosphatase III
  • Phosphatase IV
  • Phosphatase SP
  • Phosphoprotein phosphatase
  • Phosphopyruvate dehydrogenase phosphatase
  • Phosphospectrin phosphatase
  • Polycation modulated (PCM-) phosphatase
  • Protein D phosphatase
  • Protein phosphatase
  • Protein phosphatase-1
  • Protein phosphatase-2A
  • Protein phosphatase-2B
  • Protein phosphatase-2C
  • Serine/threonine specific protein phosphatase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF10409
Domain description: C2 domain of PTEN tumour-suppressor protein
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
The deposited structure of PDB entry 7juk contains 1 copy of Pfam domain PF10409 (C2 domain of PTEN tumour-suppressor protein) in Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN. Showing 1 copy in chain A.

PF00102
Domain description: Protein-tyrosine phosphatase
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
The deposited structure of PDB entry 7juk contains 1 copy of Pfam domain PF00102 (Protein-tyrosine phosphatase) in Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014020
Domain description: Tensin phosphatase, C2 domain
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
IPR029021
Domain description: Protein-tyrosine phosphatase-like
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
IPR017361
Domain description: Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
IPR035892
Domain description: C2 domain superfamily
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
IPR016130
Domain description: Protein-tyrosine phosphatase, active site
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
IPR000387
Domain description: Tyrosine-specific protein phosphatases domain
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
IPR045101
Domain description: PTEN, phosphatase domain
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
IPR003595
Domain description: Protein-tyrosine phosphatase, catalytic
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
IPR029023
Domain description: Tensin-type phosphatase domain
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

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