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ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation

Electron Microscopy
4Å resolution
PDB entry 7jpr coloured by chain, front view.
PDB entry 7jpr coloured by chain, side view.
PDB entry 7jpr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Origin recognition complex
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Multimeric state: hetero pentamer
Accessible surface area: 94607.56 Å2
Buried surface area: 26122.64 Å2
Dissociation area: 4,064.13 Å2
Dissociation energy (ΔGdiss): 48.24 kcal/mol
Dissociation entropy (TΔSdiss): 15.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129160

Macromolecules

Origin recognition complex subunit 1
Chain: A
Length: 392 amino acids
Theoretical weight: 44.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13415 (Residues: 471-861; Coverage: 45%)
Gene names: ORC1, ORC1L, PARC1
Pfam:
InterPro:
Origin recognition complex subunit 1 in PDB entry 7jpr, assembly 1, front view.
Origin recognition complex subunit 1 in PDB entry 7jpr, assembly 1, side view.
Origin recognition complex subunit 1 in PDB entry 7jpr, assembly 1, top view.
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Origin recognition complex subunit 2
Chain: B
Length: 577 amino acids
Theoretical weight: 66.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13416 (Residues: 1-577; Coverage: 100%)
Gene names: ORC2, ORC2L
Pfam: Origin recognition complex subunit 2
InterPro: Origin recognition complex, subunit 2
Origin recognition complex subunit 2 in PDB entry 7jpr, assembly 1, front view.
Origin recognition complex subunit 2 in PDB entry 7jpr, assembly 1, side view.
Origin recognition complex subunit 2 in PDB entry 7jpr, assembly 1, top view.
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Origin recognition complex subunit 3
Chain: C
Length: 712 amino acids
Theoretical weight: 82.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UBD5 (Residues: 1-505, 506-711; Coverage: 100%)
Gene names: LATHEO, ORC3, ORC3L
Pfam:
InterPro:
Origin recognition complex subunit 3 in PDB entry 7jpr, assembly 1, front view.
Origin recognition complex subunit 3 in PDB entry 7jpr, assembly 1, side view.
Origin recognition complex subunit 3 in PDB entry 7jpr, assembly 1, top view.
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Origin recognition complex subunit 4
Chain: D
Length: 436 amino acids
Theoretical weight: 50.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43929 (Residues: 1-436; Coverage: 100%)
Gene names: ORC4, ORC4L
Pfam:
InterPro:
Origin recognition complex subunit 4 in PDB entry 7jpr, assembly 1, front view.
Origin recognition complex subunit 4 in PDB entry 7jpr, assembly 1, side view.
Origin recognition complex subunit 4 in PDB entry 7jpr, assembly 1, top view.
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Origin recognition complex subunit 5
Chain: E
Length: 435 amino acids
Theoretical weight: 50.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43913 (Residues: 1-435; Coverage: 100%)
Gene names: ORC5, ORC5L
Pfam:
InterPro:
Origin recognition complex subunit 5 in PDB entry 7jpr, assembly 1, front view.
Origin recognition complex subunit 5 in PDB entry 7jpr, assembly 1, side view.
Origin recognition complex subunit 5 in PDB entry 7jpr, assembly 1, top view.
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