7jpp

Electron Microscopy
3.7Å resolution

ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain

Released:

Function and Biology Details

Biochemical function:
Biological process:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Origin recognition complex subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 392 amino acids
Theoretical weight: 44.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13415 (Residues: 471-861; Coverage: 45%)
Gene names: ORC1, ORC1L, PARC1
Sequence domains:
Origin recognition complex subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 577 amino acids
Theoretical weight: 66.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13416 (Residues: 1-577; Coverage: 100%)
Gene names: ORC2, ORC2L
Sequence domains: Origin recognition complex subunit 2
Origin recognition complex subunit 3 Chain: C
Molecule details ›
Chain: C
Length: 712 amino acids
Theoretical weight: 82.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UBD5 (Residues: 1-505, 506-711; Coverage: 100%)
Gene names: LATHEO, ORC3, ORC3L
Sequence domains:
Origin recognition complex subunit 4 Chain: D
Molecule details ›
Chain: D
Length: 436 amino acids
Theoretical weight: 50.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43929 (Residues: 1-436; Coverage: 100%)
Gene names: ORC4, ORC4L
Sequence domains:
Origin recognition complex subunit 5 Chain: E
Molecule details ›
Chain: E
Length: 435 amino acids
Theoretical weight: 50.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43913 (Residues: 1-435; Coverage: 100%)
Gene names: ORC5, ORC5L
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-22418
Expression system: Spodoptera frugiperda