X-ray diffraction
1.2Å resolution

Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with ZN1-99

Source organism: Homo sapiens
Entry authors: Ratia KM, Xiong R, Li Y, Shen Z, Zhao J, Huang F, Dubrovyskyii O, Thatcher GR

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 38.187Å b: 42.229Å c: 90.627Å
α: 90° β: 90° γ: 90°
R R work R free
0.17 0.169 0.185
Expression system: Escherichia coli BL21(DE3)