› 7jgq

X-ray diffraction
3.01Å resolution

Crystal Structure of the Ni-bound Human Heavy-chain variant 122H-delta C-star with 2,5-furandihyrdoxamate collected at 278K after one heating/cooling cycle

Released:
DOI: 10.2210/pdb7jgq/pdb
PDB entry 7jgq coloured by chain, front view.
PDB entry 7jgq coloured by chain, side view.
PDB entry 7jgq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tunable and Cooperative Thermomechanical Properties of Protein-Metal-Organic Frameworks.
Bailey JB, Tezcan FA
J Am Chem Soc 142 17265-17270 (2020)
PMID: 32972136

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 100%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain

Ligands and Environments

3 bound ligands:
Ligand V9Y 1 x V9Y
Ligand NI 3 x NI
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: I432
Unit cell:
a: 156.142Å b: 156.142Å c: 156.142Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.195 0.251
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Protein Assembly by Design.
Zhu et al. (2021)
1 more