› 7jgh

Electron Microscopy
3.36Å resolution

Cryo-EM structure of P. falciparum VAR2CSA NF54 core in complex with CSA at 3.36 A

Released:
DOI: 10.2210/pdb7jgh/pdb
PDB 7jgh coloured by chain and viewed from the front.
PDB 7jgh coloured by chain and viewed from the side.
PDB 7jgh coloured by chain and viewed from the top.
Source organism: Plasmodium falciparum NF54
Primary publication:
Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
Ma R, Lian T, Huang R, Renn JP, Petersen JD, Zimmerberg J, Duffy PE, Tolia NH
Nat Microbiol (2021)
PMID: 33452495
Related structures: EMD-22327

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Erythrocyte membrane protein 1 Chain: A
Molecule details ›
Chain: A
Length: 2653 amino acids
Theoretical weight: 308.71 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Homo sapiens
UniProt:
  • Canonical: W7K270 (Residues: 1-2642; Coverage: 94%)
Gene name: PFNF54_03544
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: ASG, BDP
Ligand ASG 5 x ASG
Ligand BDP 6 x BDP
1 bound ligand:
Ligand ASG 1 x ASG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.36Å
Relevant EMDB volumes: EMD-22327
Expression system: Homo sapiens

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