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Crystal structure of human phosphorylated IRF-3 bound to CBP

Source organism: Homo sapiens
Biochemical function: histone acetyltransferase activity
Biological process: regulation of DNA-templated transcription
Cellular component: nucleus

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF09030
Domain description: Creb binding
Occurring in:
  1. CREB-binding protein
The deposited structure of PDB entry 7jfl contains 2 copies of Pfam domain PF09030 (Creb binding) in CREB-binding protein. Showing 1 copy in chain D.

PF10401
Domain description: Interferon-regulatory factor 3
Occurring in:
  1. Interferon regulatory factor 3
The deposited structure of PDB entry 7jfl contains 2 copies of Pfam domain PF10401 (Interferon-regulatory factor 3) in Interferon regulatory factor 3. Showing 1 copy in chain C [auth B].

InterPro InterPro annotations
IPR019471
Domain description: Interferon regulatory factor-3
Occurring in:
  1. Interferon regulatory factor 3
IPR021714
Domain description: Nucleolar pre-ribosomal-associated protein 1, N-terminal
Occurring in:
  1. CREB-binding protein
IPR037073
Domain description: Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily
Occurring in:
  1. CREB-binding protein
IPR014744
Domain description: Nuclear receptor coactivator, CREB-bp-like, interlocking
Occurring in:
  1. CREB-binding protein
IPR009110
Domain description: Nuclear receptor coactivator, interlocking
Occurring in:
  1. CREB-binding protein
IPR008984
Domain description: SMAD/FHA domain superfamily
Occurring in:
  1. Interferon regulatory factor 3
IPR017855
Domain description: SMAD-like domain superfamily
Occurring in:
  1. Interferon regulatory factor 3

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