7jfl

X-ray diffraction
1.68Å resolution

Crystal structure of human phosphorylated IRF-3 bound to CBP

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon regulatory factor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14653 (Residues: 189-398; Coverage: 49%)
Gene name: IRF3
Sequence domains: Interferon-regulatory factor 3
CREB-binding protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 47 amino acids
Theoretical weight: 5.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92793 (Residues: 2065-2111; Coverage: 2%)
Gene names: CBP, CREBBP

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2
Unit cell:
a: 124.01Å b: 68.03Å c: 55.92Å
α: 90° β: 106.24° γ: 90°
R-values:
R R work R free
0.193 0.191 0.223
Expression system: Escherichia coli BL21(DE3)