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DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF CDCL2

X-ray diffraction
3Å resolution
PDB entry 7icg coloured by chain, front view.
PDB entry 7icg coloured by chain, side view.
PDB entry 7icg coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA polymerase beta and DNA
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Multimeric state: hetero trimer
Accessible surface area: 19090.6 Å2
Buried surface area: 1817.54 Å2
Dissociation area: 540.12 Å2
Dissociation energy (ΔGdiss): 9.36 kcal/mol
Dissociation entropy (TΔSdiss): 8.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-121288

Macromolecules

DNA polymerase beta
Chain: A
Length: 335 amino acids
Theoretical weight: 38.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06746 (Residues: 1-335; Coverage: 100%)
Gene name: POLB
Pfam:
InterPro:
CATH:
SCOP:
DNA polymerase beta in PDB entry 7icg, assembly 1, front view.
DNA polymerase beta in PDB entry 7icg, assembly 1, side view.
DNA polymerase beta in PDB entry 7icg, assembly 1, top view.
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DNA chain T
Name: DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3')
Representative chains: T
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 7 nucleotides
Theoretical weight: 2.09 KDa
DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3') in PDB entry 7icg, assembly 1, front view.
DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3') in PDB entry 7icg, assembly 1, side view.
DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3') in PDB entry 7icg, assembly 1, top view.
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DNA chain P
Name: DNA (5'-D(*CP*AP*GP*AP*TP*G)-3')
Representative chains: P
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 6 nucleotides
Theoretical weight: 1.83 KDa
DNA (5'-D(*CP*AP*GP*AP*TP*G)-3') in PDB entry 7icg, assembly 1, front view.
DNA (5'-D(*CP*AP*GP*AP*TP*G)-3') in PDB entry 7icg, assembly 1, side view.
DNA (5'-D(*CP*AP*GP*AP*TP*G)-3') in PDB entry 7icg, assembly 1, top view.
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