› 7fxv

X-ray diffraction
0.88Å resolution

Crystal Structure of human FABP4 in complex with 6-[(4-methoxyphenyl)methyl]-2H-1,2,4-triazine-3,5-dithione

Released:
DOI: 10.2210/pdb7fxv/pdb
PDB entry 7fxv coloured by chain, front view.
PDB entry 7fxv coloured by chain, side view.
PDB entry 7fxv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ehler A, Benz J, Obst U, Koch W, Rudolph MG

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, adipocyte Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15090 (Residues: 1-132; Coverage: 100%)
Gene name: FABP4
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family

Ligands and Environments

4 bound ligands:
Ligand DMS 2 x DMS
Ligand U8H 1 x U8H
Ligand EDO 1 x EDO
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 32.532Å b: 53.809Å c: 74.951Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.142 0.141 0.166
Expression system: Escherichia coli BL21(DE3)

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