7feh

X-ray diffraction
1.61Å resolution

Crystal structure of human DDR1 in complex with CH5541127

Released:
Source organism: Homo sapiens
Entry authors: Fukami TA, Kadono S, Matsuura T

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epithelial discoidin domain-containing receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 320 amino acids
Theoretical weight: 36.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q08345 (Residues: 593-913; Coverage: 35%)
Gene names: CAK, DDR1, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 40.39Å b: 61.7Å c: 63.11Å
α: 90° β: 106.22° γ: 90°
R-values:
R R work R free
0.168 0.166 0.206
Expression system: Spodoptera frugiperda