› 7fea

X-ray diffraction
1.4Å resolution

PY14 in complex with Col-D

Released:
DOI: 10.2210/pdb7fea/pdb
PDB entry 7fea coloured by chain, front view.
PDB entry 7fea coloured by chain, side view.
PDB entry 7fea coloured by chain, top view.
Source organism: Massilia sp. YMA4
Primary publication:
Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Lin CC, Hoo SY, Ma LT, Lin C, Huang KF, Ho YN, Sun CH, Lee HJ, Chen PY, Shu LJ, Wang BW, Hsu WC, Ko TP, Yang YL
Commun Biol 5 454 (2022)
PMID: 35551233

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105929 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl-CoA acetyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 407 amino acids
Theoretical weight: 42.61 KDa
Source organism: Massilia sp. YMA4
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A7U5Y2I6 (Residues: 2-393; Coverage: 100%)
Gene name: DPH57_23275
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 3KI 4 x 3KI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE TPS 05A
Spacegroup: P1
Unit cell:
a: 66.943Å b: 77.741Å c: 98.117Å
α: 70.758° β: 81.781° γ: 64.995°
R-values:
R R work R free
0.146 0.146 0.163
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites.
Petrova et al. (2022)
4 other articles

1 mention without citation

Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Lin et al. (2022)