› 7fdk

Electron Microscopy
3.69Å resolution

SARS-COV-2 Spike RBDMACSp36 binding to mACE2

Released:
DOI: 10.2210/pdb7fdk/pdb
PDB entry 7fdk coloured by chain, front view.
PDB entry 7fdk coloured by chain, side view.
PDB entry 7fdk coloured by chain, top view.
Source organisms:
Primary publication:
Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2.
Sun S, Gu H, Cao L, Chen Q, Ye Q, Yang G, Li RT, Fan H, Deng YQ, Song X, Qi Y, Li M, Lan J, Feng R, Guo Y, Zhu N, Qin S, Wang L, Zhang YF, Zhou C, Zhao L, Chen Y, Shen M, Cui Y, Yang X, Wang X, Tan W, Wang H, Wang X, Qin CF
Nat Commun 12 5654 (2021)
PMID: 34580297
Related structures: EMD-31546

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144193 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Processed angiotensin-converting enzyme 2 Chain: A
Molecule details ›
Chain: A
Length: 621 amino acids
Theoretical weight: 71.71 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8R0I0 (Residues: 1-615; Coverage: 76%)
Gene name: Ace2
Sequence domains: Angiotensin-converting enzyme
Spike protein S1 Chain: E
Molecule details ›
Chain: E
Length: 213 amino acids
Theoretical weight: 24.1 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 333-526; Coverage: 15%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.69Å
Relevant EMDB volumes: EMD-31546
Expression system: Homo sapiens

Quick links

Citations

14 review citations

The variant gambit: COVID-19's next move.
Plante et al. (2021)
13 more

4 mentions without citation

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2.
Sun et al. (2021)
3 more