› 7f1q

Electron Microscopy
2.9Å resolution

Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi

Released:
DOI: 10.2210/pdb7f1q/pdb
PDB entry 7f1q coloured by chain, front view.
PDB entry 7f1q coloured by chain, side view.
PDB entry 7f1q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Zhang H, Chen K, Tan Q, Shao Q, Han S, Zhang C, Yi C, Chu X, Zhu Y, Xu Y, Zhao Q, Wu B
Nat Commun 12 4151 (2021)
PMID: 34230484
Related structures: EMD-31422

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-145186 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
C-C chemokine receptor type 5; C-C motif chemokine 3 Chain: R
Molecule details ›
Chain: R
Length: 457 amino acids
Theoretical weight: 51.24 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10147 (Residues: 24-92; Coverage: 100%)
  • Canonical: P51681 (Residues: 2-319; Coverage: 90%)
Gene names: CCL3, CCR5, CMKBR5, G0S19-1, MIP1A, SCYA3
Sequence domains:
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
Molecule details ›
Chain: C
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-31422
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

CCR5 as a Coreceptor for Human Immunodeficiency Virus and Simian Immunodeficiency Viruses: A Prototypic Love-Hate Affair.
Jasinska et al. (2022)
3 more

6 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
5 more