› 7ep2

X-ray diffraction
2.38Å resolution

Crystal structure of ZYG11B bound to GGFN degron

Released:
DOI: 10.2210/pdb7ep2/pdb
PDB entry 7ep2 coloured by chain, front view.
PDB entry 7ep2 coloured by chain, side view.
PDB entry 7ep2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for recognition of Gly/N-degrons by CRL2ZYG11B and CRL2ZER1.
Yan X, Li Y, Wang G, Zhou Z, Song G, Feng Q, Zhao Y, Mi W, Ma Z, Dong C
Mol Cell 81 3262-3274.e3 (2021)
PMID: 34214466

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189890 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein zyg-11 homolog B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 288 amino acids
Theoretical weight: 32.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9C0D3 (Residues: 443-728; Coverage: 38%)
Gene names: KIAA1730, ZYG11B

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 91.36Å b: 102.32Å c: 164.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 0.254
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Rejuvenation: Turning Back Time by Enhancing CISD2.
Yeh et al. (2022)
8 other articles

1 mention without citation

How the ends signal the end: Regulation by E3 ubiquitin ligases recognizing protein termini.
Sherpa et al. (2022)