X-ray diffraction
3Å resolution

The atomic structure of SHP2 E76A mutant


Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein phosphatase non-receptor type 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 534 amino acids
Theoretical weight: 61.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q06124 (Residues: 1-534; Coverage: 90%)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 46.2Å b: 211.45Å c: 56.1Å
α: 90° β: 96.96° γ: 90°
R R work R free
0.226 0.223 0.271
Expression system: Escherichia coli BL21(DE3)