› 7ekn

X-ray diffraction
2.14Å resolution

Crystal structure of AF10-ipep complex

Released:
DOI: 10.2210/pdb7ekn/pdb
PDB entry 7ekn coloured by chain, front view.
PDB entry 7ekn coloured by chain, side view.
PDB entry 7ekn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characteristics of coiled-coil regions in AF10-DOT1L and AF10-inhibitory peptide complex.
Zhou Z, Kang S, Huang Z, Zhou Z, Chen S
J Leukoc Biol 110 1091-1099 (2021)
PMID: 33993518

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168233 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ipep Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 43 amino acids
Theoretical weight: 5.02 KDa
Source organism: Homo sapiens
Expression system: Not provided
MLLT10 histone lysine methyltransferase DOT1L cofactor Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 43 amino acids
Theoretical weight: 5.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5JT35 (Residues: 433-475; Coverage: 6%)
Gene name: MLLT10

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P1
Unit cell:
a: 42.626Å b: 46.389Å c: 49.17Å
α: 76.669° β: 67.7° γ: 74.673°
R-values:
R R work R free
0.194 0.186 0.26
Expression systems:
  • Not provided
  • Escherichia coli

Quick links

Citations

1 review citation

Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias.
Yi et al. (2022)