› 7ehl

Electron Microscopy

Cryo-EM structure of human ABCB8 transporter in nucleotide binding state

Released:
DOI: 10.2210/pdb7ehl/pdb
PDB entry 7ehl coloured by chain, front view.
PDB entry 7ehl coloured by chain, side view.
PDB entry 7ehl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human ABCB8 transporter in nucleotide binding state.
Li S, Ren Y, Lu X, Shen Y, Yang X
Biochem Biophys Res Commun 557 187-191 (2021)
PMID: 33872987
Related structures: EMD-31142

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192620 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial potassium channel ATP-binding subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 678 amino acids
Theoretical weight: 73.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NUT2 (Residues: 58-735; Coverage: 92%)
Gene names: ABCB8, MABC1, MITOSUR
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand CLR 4 x CLR
Ligand ANP 2 x ANP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Relevant EMDB volumes: EMD-31142
Expression system: Spodoptera frugiperda

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Citations

1 review citation

To Be or Not to Be an Ion Channel: Cryo-EM Structures Have a Say.
Chen et al. (2023)
1 other article