7eas

X-ray diffraction
1.97Å resolution

Crystal structure of human pyruvate dehydrogenase kinase 2 in complex with compound 2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-172222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 44.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15119 (Residues: 16-407; Coverage: 96%)
Gene names: PDHK2, PDK2
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P64
Unit cell:
a: 109.317Å b: 109.317Å c: 85.087Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.196 0.208
Expression system: Escherichia coli BL21(DE3)