7e7o

Electron Microscopy
3.4Å resolution

Cryo-EM structure of human ABCA4 in NRPE-bound state

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis of substrate recognition and translocation by human ABCA4.
Nat Commun 12 3853 (2021)
PMID: 34158497
Related structures: EMD-31001

Function and Biology Details

Reaction catalysed:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Biochemical function:
Biological process:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Retinal-specific phospholipid-transporting ATPase ABCA4 Chain: A
Molecule details ›
Chain: A
Length: 2317 amino acids
Theoretical weight: 261.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P78363 (Residues: 1-2273; Coverage: 100%)
Gene names: ABCA4, ABCR
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-31001
Expression system: Homo sapiens