› 7dkf

Electron Microscopy
8.3Å resolution

Activity optimized supercomplex state4

Released:
DOI: 10.2210/pdb7dkf/pdb
PDB entry 7dkf coloured by chain, front view.
PDB entry 7dkf coloured by chain, side view.
PDB entry 7dkf coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex.
Jeon TJ, Lee SG, Yoo SH, Kim M, Song D, Ryu J, Park H, Kim DS, Hyun J, Kim HM, Ryu SE
Antioxid Redox Signal (2022)
PMID: 34913730
Related structures: EMD-30706

Function and Biology Details

Reactions catalysed: 
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 80-mer (preferred)
PDBe Complex ID:
PDB-CPX-132191 (preferred)
Entry contents:
68 distinct polypeptide molecules
Macromolecules (68 distinct):
Cytochrome b-c1 complex subunit 1, mitochondrial Chains: A1, M1
Molecule details ›
Chains: A1, M1
Length: 480 amino acids
Theoretical weight: 52.8 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P31800 (Residues: 1-480; Coverage: 100%)
Gene name: UQCRC1
Sequence domains:
Cytochrome b-c1 complex subunit 2, mitochondrial Chains: B1, N1
Molecule details ›
Chains: B1, N1
Length: 453 amino acids
Theoretical weight: 48.2 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23004 (Residues: 1-453; Coverage: 100%)
Gene name: UQCRC2
Sequence domains:
Cytochrome b Chains: C1, O1
Molecule details ›
Chains: C1, O1
Length: 379 amino acids
Theoretical weight: 42.62 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00157 (Residues: 1-379; Coverage: 100%)
Gene names: COB, CYTB, MT-CYB, MTCYB
Sequence domains:
Cytochrome c1, heme protein, mitochondrial Chains: D1, P1
Molecule details ›
Chains: D1, P1
Length: 325 amino acids
Theoretical weight: 35.34 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00125 (Residues: 1-325; Coverage: 100%)
Gene name: CYC1
Sequence domains: Cytochrome C1 family
Cytochrome b-c1 complex subunit Rieske, mitochondrial Chains: E1, Q1
Molecule details ›
Chains: E1, Q1
Length: 196 amino acids
Theoretical weight: 21.64 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13272 (Residues: 79-274; Coverage: 72%)
Gene name: UQCRFS1
Sequence domains:
Cytochrome b-c1 complex subunit 7 Chains: F1, R1
Molecule details ›
Chains: F1, R1
Length: 111 amino acids
Theoretical weight: 13.5 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00129 (Residues: 1-111; Coverage: 100%)
Gene name: UQCRB
Sequence domains: Ubiquinol-cytochrome C reductase complex 14kD subunit
Cytochrome b-c1 complex subunit 8 Chains: G1, S1
Molecule details ›
Chains: G1, S1
Length: 82 amino acids
Theoretical weight: 9.74 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13271 (Residues: 1-82; Coverage: 100%)
Gene name: UQCRQ
Sequence domains: UcrQ family
Cytochrome b-c1 complex subunit 6, mitochondrial Chains: H1, T1
Molecule details ›
Chains: H1, T1
Length: 91 amino acids
Theoretical weight: 10.64 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00126 (Residues: 1-91; Coverage: 100%)
Gene name: UQCRH
Sequence domains: Ubiquinol-cytochrome C reductase hinge protein
Cytochrome b-c1 complex subunit 9 Chains: I1, U1
Molecule details ›
Chains: I1, U1
Length: 78 amino acids
Theoretical weight: 7.96 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13272 (Residues: 1-78; Coverage: 29%)
Gene name: UQCRFS1
Sequence domains: Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
Cytochrome b-c1 complex subunit 9 Chains: J1, V1
Molecule details ›
Chains: J1, V1
Length: 64 amino acids
Theoretical weight: 7.47 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00130 (Residues: 1-64; Coverage: 100%)
Gene name: UQCR10
Sequence domains: Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
Cytochrome b-c1 complex subunit 10 Chains: K1, W1
Molecule details ›
Chains: K1, W1
Length: 56 amino acids
Theoretical weight: 6.53 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07552 (Residues: 1-56; Coverage: 100%)
Gene names: UQCR, UQCR11
Sequence domains: Ubiquinol-cytochrome C reductase complex, 6.4kD protein
NADH-ubiquinone oxidoreductase chain 2 Chain: 22
Molecule details ›
Chain: 22
Length: 347 amino acids
Theoretical weight: 39.27 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03892 (Residues: 1-347; Coverage: 100%)
Gene names: MT-ND2, MTND2, NADH2, ND2
Sequence domains:
NADH-ubiquinone oxidoreductase chain 3 Chain: 32
Molecule details ›
Chain: 32
Length: 115 amino acids
Theoretical weight: 13.06 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03898 (Residues: 1-115; Coverage: 100%)
Gene names: MT-ND3, MTND3, NADH3, ND3
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
NADH-ubiquinone oxidoreductase chain 4 Chain: 42
Molecule details ›
Chain: 42
Length: 459 amino acids
Theoretical weight: 52.13 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03910 (Residues: 1-459; Coverage: 100%)
Gene names: MT-ND4, MTND4, NADH4, ND4
Sequence domains:
NADH-ubiquinone oxidoreductase chain 4L Chain: 52
Molecule details ›
Chain: 52
Length: 98 amino acids
Theoretical weight: 10.8 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03902 (Residues: 1-98; Coverage: 100%)
Gene names: MT-ND4L, MTND4L, NADH4L, ND4L
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
NADH-ubiquinone oxidoreductase chain 6 Chain: 72
Molecule details ›
Chain: 72
Length: 175 amino acids
Theoretical weight: 19.08 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03924 (Residues: 1-175; Coverage: 100%)
Gene names: MT-ND6, MTND6, NADH6, ND6
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Chain: 82
Molecule details ›
Chain: 82
Length: 444 amino acids
Theoretical weight: 48.56 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P25708 (Residues: 21-464; Coverage: 96%)
Gene names: NDUFV1, UQOR1
Sequence domains:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Chain: 92
Molecule details ›
Chain: 92
Length: 217 amino acids
Theoretical weight: 23.84 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P04394 (Residues: 33-249; Coverage: 87%)
Gene name: NDUFV2
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Chain: A2
Molecule details ›
Chain: A2
Length: 704 amino acids
Theoretical weight: 77.04 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P15690 (Residues: 24-727; Coverage: 97%)
Gene name: NDUFS1
Sequence domains:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Chain: B2
Molecule details ›
Chain: B2
Length: 430 amino acids
Theoretical weight: 49.21 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P17694 (Residues: 34-463; Coverage: 93%)
Gene name: NDUFS2
Sequence domains: Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Chain: C2
Molecule details ›
Chain: C2
Length: 228 amino acids
Theoretical weight: 26.46 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23709 (Residues: 39-266; Coverage: 86%)
Gene name: NDUFS3
Sequence domains: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Chain: D2
Molecule details ›
Chain: D2
Length: 179 amino acids
Theoretical weight: 20.1 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P42026 (Residues: 38-216; Coverage: 83%)
Gene name: NDUFS7
Sequence domains: NADH ubiquinone oxidoreductase, 20 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Chain: E2
Molecule details ›
Chain: E2
Length: 176 amino acids
Theoretical weight: 20.22 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P42028 (Residues: 37-212; Coverage: 83%)
Gene name: NDUFS8
Sequence domains: 4Fe-4S dicluster domain
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Chain: F2
Molecule details ›
Chain: F2
Length: 75 amino acids
Theoretical weight: 8.45 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P25712 (Residues: 35-109; Coverage: 69%)
Gene name: NDUFV3
Sequence domains: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Chain: G2
Molecule details ›
Chain: G2
Length: 133 amino acids
Theoretical weight: 15.36 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02375 (Residues: 43-175; Coverage: 76%)
Gene name: NDUFS4
Sequence domains: NADH dehydrogenase ubiquinone Fe-S protein 4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Chain: H2
Molecule details ›
Chain: H2
Length: 105 amino acids
Theoretical weight: 12.56 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02379 (Residues: 2-106; Coverage: 99%)
Gene name: NDUFS5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Chain: I2
Molecule details ›
Chain: I2
Length: 96 amino acids
Theoretical weight: 10.55 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23934 (Residues: 29-124; Coverage: 77%)
Gene name: NDUFS6
Sequence domains: Zinc-finger domain
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Chain: J2
Molecule details ›
Chain: J2
Length: 70 amino acids
Theoretical weight: 8.12 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02377 (Residues: 1-70; Coverage: 100%)
Gene name: NDUFA1
Sequence domains: NADH-ubiquinone oxidoreductase MWFE subunit
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Chain: K2
Molecule details ›
Chain: K2
Length: 98 amino acids
Theoretical weight: 10.97 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02370 (Residues: 2-99; Coverage: 99%)
Gene name: NDUFA2
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Chain: L2
Molecule details ›
Chain: L2
Length: 83 amino acids
Theoretical weight: 9.23 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02371 (Residues: 2-84; Coverage: 99%)
Gene name: NDUFA3
Sequence domains: NADH dehydrogenase 1 alpha subcomplex subunit 3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Chain: N2
Molecule details ›
Chain: N2
Length: 115 amino acids
Theoretical weight: 13.2 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23935 (Residues: 2-116; Coverage: 99%)
Gene name: NDUFA5
Sequence domains: ETC complex I subunit conserved region
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Chain: O2
Molecule details ›
Chain: O2
Length: 127 amino acids
Theoretical weight: 14.95 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02366 (Residues: 2-128; Coverage: 99%)
Gene name: NDUFA6
Sequence domains: Complex1_LYR-like
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Chain: P2
Molecule details ›
Chain: P2
Length: 112 amino acids
Theoretical weight: 12.56 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q05752 (Residues: 2-113; Coverage: 99%)
Gene names: CI-B14-5A, NDUFA7
Sequence domains: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Chain: Q2
Molecule details ›
Chain: Q2
Length: 171 amino acids
Theoretical weight: 19.99 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P42029 (Residues: 2-172; Coverage: 99%)
Gene name: NDUFA8
Sequence domains: CHCH domain
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Chain: R2
Molecule details ›
Chain: R2
Length: 345 amino acids
Theoretical weight: 39.17 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P34943 (Residues: 36-380; Coverage: 91%)
Gene name: NDUFA9
Sequence domains: NAD dependent epimerase/dehydratase family
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Chain: S2
Molecule details ›
Chain: S2
Length: 320 amino acids
Theoretical weight: 36.74 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P34942 (Residues: 24-343; Coverage: 93%)
Gene name: NDUFA10
Sequence domains: Deoxynucleoside kinase
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Chain: T2
Molecule details ›
Chain: T2
Length: 140 amino acids
Theoretical weight: 14.64 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q8HXG6 (Residues: 2-141; Coverage: 99%)
Gene name: NDUFA11
Sequence domains: Tim17/Tim22/Tim23/Pmp24 family
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Chain: U2
Molecule details ›
Chain: U2
Length: 145 amino acids
Theoretical weight: 17.12 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: O97725 (Residues: 1-145; Coverage: 100%)
Gene name: NDUFA12
Sequence domains: NADH ubiquinone oxidoreductase subunit NDUFA12
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Chain: V2
Molecule details ›
Chain: V2
Length: 143 amino acids
Theoretical weight: 16.56 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q95KV7 (Residues: 2-144; Coverage: 99%)
Gene names: GRIM19, NDUFA13
Sequence domains: GRIM-19 protein
Acyl carrier protein, mitochondrial Chains: M2, W2
Molecule details ›
Chains: M2, W2
Length: 88 amino acids
Theoretical weight: 10.12 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P52505 (Residues: 69-156; Coverage: 56%)
Gene name: NDUFAB1
Sequence domains: Phosphopantetheine attachment site
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Chain: X2
Molecule details ›
Chain: X2
Length: 57 amino acids
Theoretical weight: 6.98 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02378 (Residues: 1-57; Coverage: 100%)
Gene name: NDUFB1
Sequence domains: MNLL subunit
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Chain: Y2
Molecule details ›
Chain: Y2
Length: 72 amino acids
Theoretical weight: 8.5 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02374 (Residues: 37-108; Coverage: 67%)
Gene name: NDUFB2
Sequence domains: NADH dehydrogenase 1 beta subcomplex subunit 2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Chain: Z2
Molecule details ›
Chain: Z2
Length: 97 amino acids
Theoretical weight: 11.03 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02365 (Residues: 2-98; Coverage: 99%)
Gene name: NDUFB3
Sequence domains: NADH-ubiquinone oxidoreductase B12 subunit family
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Chain: a2
Molecule details ›
Chain: a2
Length: 128 amino acids
Theoretical weight: 15.08 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P48305 (Residues: 2-129; Coverage: 99%)
Gene name: NDUFB4
Sequence domains: NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Chain: b2
Molecule details ›
Chain: b2
Length: 143 amino acids
Theoretical weight: 16.75 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02380 (Residues: 47-189; Coverage: 76%)
Gene name: NDUFB5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Chain: c2
Molecule details ›
Chain: c2
Length: 127 amino acids
Theoretical weight: 15.42 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02367 (Residues: 2-128; Coverage: 99%)
Gene name: NDUFB6
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Chain: d2
Molecule details ›
Chain: d2
Length: 136 amino acids
Theoretical weight: 16.3 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02368 (Residues: 2-137; Coverage: 99%)
Gene name: NDUFB7
Sequence domains: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Chain: f2
Molecule details ›
Chain: f2
Length: 178 amino acids
Theoretical weight: 21.7 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02369 (Residues: 2-179; Coverage: 99%)
Gene names: NDUFB9, UQOR22
Sequence domains: Complex 1 protein (LYR family)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Chain: h2
Molecule details ›
Chain: h2
Length: 125 amino acids
Theoretical weight: 14.47 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q8HXG5 (Residues: 30-154; Coverage: 81%)
Gene name: NDUFB11
Sequence domains: ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Chain: i2
Molecule details ›
Chain: i2
Length: 49 amino acids
Theoretical weight: 5.84 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02376 (Residues: 28-76; Coverage: 65%)
Gene name: NDUFC1
Sequence domains: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
NADH dehydrogenase [ubiquinone] 1 subunit C2 Chain: j2
Molecule details ›
Chain: j2
Length: 120 amino acids
Theoretical weight: 14.12 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02827 (Residues: 1-120; Coverage: 100%)
Gene name: NDUFC2
Sequence domains: NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
NADH-ubiquinone oxidoreductase chain 1 Chain: 12
Molecule details ›
Chain: 12
Length: 318 amino acids
Theoretical weight: 35.69 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03887 (Residues: 1-318; Coverage: 100%)
Gene names: MT-ND1, MTND1, NADH1, ND1
Sequence domains: NADH dehydrogenase
NADH-ubiquinone oxidoreductase chain 5 Chain: 62
Molecule details ›
Chain: 62
Length: 606 amino acids
Theoretical weight: 68.33 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03920 (Residues: 1-606; Coverage: 100%)
Gene names: MT-ND5, MTND5, NADH5, ND5
Sequence domains:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Chain: g2
Molecule details ›
Chain: g2
Length: 176 amino acids
Theoretical weight: 21 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02373 (Residues: 1-176; Coverage: 100%)
Gene name: NDUFB10
Sequence domains: NADH-ubiquinone oxidoreductase subunit 10
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Chain: e2
Molecule details ›
Chain: e2
Length: 158 amino acids
Theoretical weight: 18.76 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q02372 (Residues: 29-186; Coverage: 85%)
Gene name: NDUFB8
Sequence domains: NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
Cytochrome c oxidase subunit 1 Chain: A3
Molecule details ›
Chain: A3
Length: 514 amino acids
Theoretical weight: 57.07 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00396 (Residues: 1-514; Coverage: 100%)
Gene names: COI, COXI, MT-CO1, MTCO1
Sequence domains: Cytochrome C and Quinol oxidase polypeptide I
Cytochrome c oxidase subunit 2 Chain: B3
Molecule details ›
Chain: B3
Length: 227 amino acids
Theoretical weight: 26.04 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P68530 (Residues: 1-227; Coverage: 100%)
Gene names: COII, COX2, COXII, MT-CO2, MTCO2
Sequence domains:
Cytochrome c oxidase subunit 3 Chain: C3
Molecule details ›
Chain: C3
Length: 261 amino acids
Theoretical weight: 29.96 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00415 (Residues: 1-261; Coverage: 100%)
Gene names: COIII, COXIII, MT-CO3, MTCO3
Sequence domains: Cytochrome c oxidase subunit III
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Chain: D3
Molecule details ›
Chain: D3
Length: 169 amino acids
Theoretical weight: 19.6 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00423 (Residues: 1-169; Coverage: 100%)
Gene names: COX4, COX4I1
Sequence domains: Cytochrome c oxidase subunit IV
Cytochrome c oxidase subunit 5A, mitochondrial Chain: E3
Molecule details ›
Chain: E3
Length: 152 amino acids
Theoretical weight: 16.76 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00426 (Residues: 1-152; Coverage: 100%)
Gene name: COX5A
Sequence domains: Cytochrome c oxidase subunit Va
Cytochrome c oxidase subunit 5B, mitochondrial Chain: F3
Molecule details ›
Chain: F3
Length: 129 amino acids
Theoretical weight: 13.85 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00428 (Residues: 1-129; Coverage: 100%)
Gene name: COX5B
Sequence domains: Cytochrome c oxidase subunit Vb
Cytochrome c oxidase subunit 6A2, mitochondrial Chain: G3
Molecule details ›
Chain: G3
Length: 97 amino acids
Theoretical weight: 10.82 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07471 (Residues: 1-97; Coverage: 100%)
Gene names: COX6A, COX6A2
Sequence domains: Cytochrome c oxidase subunit VIa
Cytochrome c oxidase subunit 6B1 Chain: H3
Molecule details ›
Chain: H3
Length: 86 amino acids
Theoretical weight: 10.17 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00429 (Residues: 1-86; Coverage: 100%)
Gene names: COX6B, COX6B1
Sequence domains: Cytochrome oxidase c subunit VIb
Cytochrome c oxidase subunit 6C Chain: I3
Molecule details ›
Chain: I3
Length: 74 amino acids
Theoretical weight: 8.63 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P04038 (Residues: 1-74; Coverage: 100%)
Gene name: COX6C
Sequence domains: Cytochrome c oxidase subunit VIc
Cytochrome c oxidase subunit 7A1, mitochondrial Chain: J3
Molecule details ›
Chain: J3
Length: 80 amino acids
Theoretical weight: 9.08 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07470 (Residues: 1-80; Coverage: 100%)
Gene names: COX7A, COX7A1, COX7AH
Sequence domains: Cytochrome c oxidase subunit VII
Cytochrome c oxidase subunit 7B, mitochondrial Chain: K3
Molecule details ›
Chain: K3
Length: 80 amino acids
Theoretical weight: 9.08 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P13183 (Residues: 1-80; Coverage: 100%)
Gene name: COX7B
Sequence domains: Cytochrome C oxidase chain VIIB
Cytochrome c oxidase subunit 7C, mitochondrial Chain: L3
Molecule details ›
Chain: L3
Length: 63 amino acids
Theoretical weight: 7.34 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00430 (Residues: 1-63; Coverage: 100%)
Gene names: COX7C, COX7CP1
Sequence domains: Cytochrome c oxidase subunit VIIc
Cytochrome c oxidase subunit 8B, mitochondrial Chain: M3
Molecule details ›
Chain: M3
Length: 70 amino acids
Theoretical weight: 7.65 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P10175 (Residues: 1-70; Coverage: 100%)
Gene names: COX8B, COX8H
Sequence domains: Cytochrome oxidase c subunit VIII

Ligands and Environments

13 bound ligands:
Ligand HEM 4 x HEM
Ligand HEC 2 x HEC
Ligand FES 3 x FES
Ligand 3PE 3 x 3PE
Ligand CDL 1 x CDL
Ligand FMN 1 x FMN
Ligand SF4 6 x SF4
Ligand ZN 2 x ZN
Ligand NAP 1 x NAP
Ligand PC1 2 x PC1
Ligand HEA 2 x HEA
Ligand CU 3 x CU
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8.3Å
Relevant EMDB volumes: EMD-30706

Quick links

Citations

1 review citation

An evolving view of complex II-noncanonical complexes, megacomplexes, respiration, signaling, and beyond.
Iverson et al. (2023)