7ctg

Electron Microscopy
5Å resolution

Human Origin Recognition Complex, ORC1-5 State I

Released:
Source organism: Homo sapiens
Related structures: EMD-30464

Function and Biology Details

Biochemical function:
Biological process:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Origin recognition complex subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 861 amino acids
Theoretical weight: 97.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13415 (Residues: 1-861; Coverage: 100%)
Gene names: ORC1, ORC1L, PARC1
Sequence domains:
Origin recognition complex subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 577 amino acids
Theoretical weight: 66.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13416 (Residues: 1-577; Coverage: 100%)
Gene names: ORC2, ORC2L
Sequence domains: Origin recognition complex subunit 2
Origin recognition complex subunit 3 Chain: C
Molecule details ›
Chain: C
Length: 711 amino acids
Theoretical weight: 82.37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UBD5 (Residues: 1-711; Coverage: 100%)
  • Best match: Q9UBD5-2 (Residues: 1-712)
Gene names: LATHEO, ORC3, ORC3L
Sequence domains:
Origin recognition complex subunit 4 Chain: D
Molecule details ›
Chain: D
Length: 436 amino acids
Theoretical weight: 50.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43929 (Residues: 1-436; Coverage: 100%)
Gene names: ORC4, ORC4L
Sequence domains:
Origin recognition complex subunit 5 Chain: E
Molecule details ›
Chain: E
Length: 435 amino acids
Theoretical weight: 50.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43913 (Residues: 1-435; Coverage: 100%)
Gene names: ORC5, ORC5L
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-30464
Expression system: Spodoptera frugiperda