7cr5

X-ray diffraction
2.08Å resolution

Complex structure of a human monoclonal antibody with SARS-CoV-2 nucleocapsid protein NTD

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-210446 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Nucleoprotein Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 14.75 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTC9 (Residues: 41-174; Coverage: 32%)
Gene name: N
Sequence domains: Coronavirus nucleocapsid
monoclonal antibody chain H Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
monoclonal antibody chain L Chain: L
Molecule details ›
Chain: L
Length: 217 amino acids
Theoretical weight: 23.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P21212
Unit cell:
a: 154.065Å b: 52.596Å c: 85.299Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.191 0.222
Expression systems:
  • Escherichia coli
  • Homo sapiens