7cpx

Electron Microscopy
2.91Å resolution

Lovastatin nonaketide synthase

Released:
Source organism: Aspergillus terreus
Entry authors: Wang JL, Wang ZJ
Related structures: EMD-30434

Function and Biology Details

Reaction catalysed:
9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lovastatin nonaketide synthase, polyketide synthase component Chains: A, B
Molecule details ›
Chains: A, B
Length: 3046 amino acids
Theoretical weight: 336.45 KDa
Source organism: Aspergillus terreus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9Y8A5 (Residues: 1-3038; Coverage: 100%)
Gene name: lovB
Sequence domains:

Ligands and Environments


Cofactor: Ligand NAP 2 x NAP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.91Å
Relevant EMDB volumes: EMD-30434
Expression system: Saccharomyces cerevisiae