› 7cak

Electron Microscopy
3.58Å resolution

SARS-CoV-2 S trimer with three RBD in the open state and complexed with three H014 Fab

Released:
DOI: 10.2210/pdb7cak/pdb
PDB entry 7cak coloured by chain, front view.
PDB entry 7cak coloured by chain, side view.
PDB entry 7cak coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody.
Lv Z, Deng YQ, Ye Q, Cao L, Sun CY, Fan C, Huang W, Sun S, Sun Y, Zhu L, Chen Q, Wang N, Nie J, Cui Z, Zhu D, Shaw N, Li XF, Li Q, Xie L, Wang Y, Rao Z, Qin CF, Wang X
OpenAccess logo Science 369 1505-1509 (2020)
PMID: 32703908
Related structures: EMD-30333

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210141 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1208 amino acids
Theoretical weight: 133.87 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
Light chain of H014 Fab Chains: D, F, H
Molecule details ›
Chains: D, F, H
Length: 210 amino acids
Theoretical weight: 23.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Heavy chain of H014 Fab Chains: E, G, I
Molecule details ›
Chains: E, G, I
Length: 223 amino acids
Theoretical weight: 23.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 30 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.58Å
Relevant EMDB volumes: EMD-30333
Expression system: Homo sapiens

Quick links

Citations

82 review citations

The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens.
Duan et al. (2020)
81 more

21 mentions without citation

Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment.
Valdez-Cruz et al. (2021)
20 more