X-ray diffraction
2.85Å resolution

Atrial Natriuretic Peptide Receptor complexed with deletion mutant of human Atrial Natriuretic Peptide[5-27]

Source organisms:
Entry author: Ogawa H

Function and Biology Details

Reaction catalysed:
GTP = 3',5'-cyclic GMP + diphosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Atrial natriuretic peptide receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 435 amino acids
Theoretical weight: 48.43 KDa
Source organism: Rattus norvegicus
Expression system: Rattus norvegicus
  • Canonical: P18910 (Residues: 29-463; Coverage: 42%)
Gene name: Npr1
Sequence domains: Receptor family ligand binding region
Atriopeptin-2 Chain: L
Molecule details ›
Chain: L
Length: 23 amino acids
Theoretical weight: 2.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P01160 (Residues: 128-150; Coverage: 18%)
Gene names: ANP, NPPA, PND

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer : NEW Components: NAG, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P61
Unit cell:
a: 99.419Å b: 99.419Å c: 259.666Å
α: 90° β: 90° γ: 120°
R R work R free
0.178 0.176 0.231
Expression systems:
  • Rattus norvegicus
  • Not provided