7bn8

X-ray diffraction
1.78Å resolution

Notum fragment_3 (4H,5H-naphtho[1,2-b]thiophene-2-carboxylic acid)

Released:
Source organism: Homo sapiens
Entry authors: Zhao Y, Jones EY

Function and Biology Details

Reaction catalysed:
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H(2)O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Palmitoleoyl-protein carboxylesterase NOTUM Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 43.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P988 (Residues: 81-451; Coverage: 78%)
Gene names: NOTUM, OK/SW-CL.30
Sequence domains: Pectinacetylesterase

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 60.44Å b: 72.426Å c: 79.347Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.232
Expression system: Homo sapiens