X-ray diffraction
1.88Å resolution

Crystal structure of 3-hydroxydecanoyl-acyl carrier protein dehydratase (FabA) from Pseudomonas aeruginosa in complex with DDD01870824

Source organism: Pseudomonas aeruginosa PAO1
Entry authors: Moynie L, Naismith JH

Function and Biology Details

Reactions catalysed:
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
Trans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein]
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 171 amino acids
Theoretical weight: 18.77 KDa
Source organism: Pseudomonas aeruginosa PAO1
Expression system: Escherichia coli
  • Canonical: O33877 (Residues: 1-171; Coverage: 100%)
Gene names: PA1610, fabA
Sequence domains: FabA-like domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 113.67Å b: 142.03Å c: 77.9Å
α: 90° β: 114.14° γ: 90°
R R work R free
0.197 0.196 0.217
Expression system: Escherichia coli