7bi9

X-ray diffraction
2.65Å resolution

PI3KC2a core in complex with PIK90

Released:

Function and Biology Details

Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 910 amino acids
Theoretical weight: 102.49 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q61194 (Residues: 377-532, 666-1400; Coverage: 53%)
Gene names: Cpk, Pik3c2a
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 55.943Å b: 135.397Å c: 151.603Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.233 0.28
Expression system: Spodoptera frugiperda