X-ray diffraction
1.65Å resolution

Room temperature, serial X-ray structure of the ertapenem-derived acylenzyme of CTX-M-15 (10 min soak) collected on fixed target chips at Diamond Light Source I24


Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Beta-lactamase Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 28.29 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli
  • Canonical: G3G192 (Residues: 49-311; Coverage: 85%)
Gene name: blaCTX-M-15
Sequence domains: Beta-lactamase enzyme family

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 45.258Å b: 45.975Å c: 119.032Å
α: 90° β: 90° γ: 90°
R R work R free
0.163 0.162 0.193
Expression system: Escherichia coli