7bfq

Electron Microscopy
3.5Å resolution

Structure of the Integrator cleavage module with extended INTS4 and rigid body docked INTS9/11 CTD

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the catalytic core of the Integrator complex.
Mol Cell (2021)
PMID: 33548203
Related structures: EMD-12166

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Integrator complex subunit 9 Chain: A
Molecule details ›
Chain: A
Length: 658 amino acids
Theoretical weight: 73.89 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NV88 (Residues: 1-658; Coverage: 100%)
Gene names: INTS9, RC74
Sequence domains: Metallo-beta-lactamase superfamily domain
Integrator complex subunit 4 Chain: C
Molecule details ›
Chain: C
Length: 979 amino acids
Theoretical weight: 110.16 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96HW7 (Residues: 1-963; Coverage: 100%)
Gene names: INTS4, MSTP093
Sequence domains:
Integrator complex subunit 11 Chain: B
Molecule details ›
Chain: B
Length: 645 amino acids
Theoretical weight: 72.69 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q5TA45 (Residues: 1-600; Coverage: 100%)
Gene names: CPSF3L, INTS11, RC68
Sequence domains:
Unknown Chain: U
Molecule details ›
Chain: U
Length: 171 amino acids
Theoretical weight: 14.57 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-12166
Expression system: Trichoplusia ni