› 7be5

X-ray diffraction
1.8Å resolution

Crystal structure of MAP kinase p38 alpha in complex with inhibitor SR276

Released:
DOI: 10.2210/pdb7be5/pdb
PDB 7be5 coloured by chain and viewed from the front.
PDB 7be5 coloured by chain and viewed from the side.
PDB 7be5 coloured by chain and viewed from the top.
Source organism: Mus musculus
Entry authors: Joerger AC, Schroeder M, Roehm S, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 41.4 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 1-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand EDO 2 x EDO
Ligand TKB 1 x TKB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 65.662Å b: 72.971Å c: 76.162Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.222
Expression system: Escherichia coli

Quick links