7be4

X-ray diffraction
2.1Å resolution

Crystal structure of MAP kinase p38 alpha in complex with inhibitor SR159

Released:
Source organism: Mus musculus
Entry authors: Joerger AC, Schroeder M, Roehm S, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 41.4 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 1-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 66.46Å b: 75.24Å c: 78.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.215 0.268
Expression system: Escherichia coli