› 7bbo

X-ray diffraction
1.32Å resolution

Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group P212121

Released:
DOI: 10.2210/pdb7bbo/pdb
PDB entry 7bbo coloured by chain, front view.
PDB entry 7bbo coloured by chain, side view.
PDB entry 7bbo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Krojer T, Talon R, Fairhead M, Szykowska A, Burgess-Brown NA, Brennan PE, Arrowsmith CH, Edwards AM, Bountra C, von Delft F, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PH-interacting protein Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 128 amino acids
Theoretical weight: 15.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WWQ0 (Residues: 1315-1440; Coverage: 7%)
Gene names: DCAF14, PHIP, WDR11
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand CA 3 x CA
Ligand EDO 9 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 47.726Å b: 56.477Å c: 91.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.226
Expression system: Escherichia coli

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