› 7b8i

X-ray diffraction
2.55Å resolution

Tetragonal structure of human protein kinase CK2 catalytic subunit in complex with a heparin oligo saccharide

Released:
DOI: 10.2210/pdb7b8i/pdb
PDB entry 7b8i coloured by chain, front view.
PDB entry 7b8i coloured by chain, side view.
PDB entry 7b8i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin.
Schnitzler A, Niefind K
Eur J Med Chem 214 113223 (2021)
PMID: 33571828

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Casein kinase II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 40.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain

Ligands and Environments

Carbohydrate polymer : NEW Components: IDS, SGN
Carbohydrate polymer
2 bound ligands:
Ligand GOL 1 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43212
Unit cell:
a: 128.401Å b: 128.401Å c: 124.154Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.24
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Predictive functional, statistical and structural analysis of CSNK2A1 and CSNK2B variants linked to neurodevelopmental diseases.
Unni et al. (2022)
2 more