› 7b67

X-ray diffraction
1.45Å resolution

Function and Biology Details

Reaction catalysed: 
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleotide triphosphate diphosphatase NUDT15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 18.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NV35 (Residues: 1-18, 19-164; Coverage: 100%)
Gene names: MTH2, NUDT15
Sequence domains: NUDIX domain

Ligands and Environments

3 bound ligands:
Ligand SYW 2 x SYW
Ligand PO4 1 x PO4
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 63.431Å b: 45.71Å c: 66.339Å
α: 90° β: 115.103° γ: 90°
R-values:
R R work R free
0.168 0.167 0.197
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health.
Zhou et al. (2022)
2 other articles

1 mention without citation

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Rehling et al. (2021)