X-ray diffraction
1.75Å resolution

Crystal structure of c-MET bound by compound 1


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 33.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P08581 (Residues: 1049-1346; Coverage: 22%)
Gene name: MET
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 111.38Å b: 42.59Å c: 85.88Å
α: 90° β: 120.74° γ: 90°
R R work R free
0.172 0.171 0.192
Expression system: Escherichia coli