› 7b2d

X-ray diffraction
1.96Å resolution

Complement inhibitor CirpA1 from Rhipicephalus pulchellus

Released:
DOI: 10.2210/pdb7b2d/pdb
PDB 7b2d coloured by chain and viewed from the front.
PDB 7b2d coloured by chain and viewed from the side.
PDB 7b2d coloured by chain and viewed from the top.
Source organism: Rhipicephalus pulchellus
Primary publication:
Structure and function of a family of tick-derived complement inhibitors targeting properdin.
Braunger K, Ahn J, Jore MM, Johnson S, Tang TTL, Pedersen DV, Andersen GR, Lea SM
Nat Commun 13 317 (2022)
PMID: 35031611

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CirpA1 Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 20.43 KDa
Source organism: Rhipicephalus pulchellus
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand MLT 2 x MLT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P2221
Unit cell:
a: 72.676Å b: 45.806Å c: 57.453Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.219
Expression system: Escherichia coli

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