7ayq

X-ray diffraction
2.45Å resolution

Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B114

Released:
Source organism: Homo sapiens
Entry authors: Ross B, Huber R

Function and Biology Details

Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 898 amino acids
Theoretical weight: 103.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6V1X1 (Residues: 1-898; Coverage: 100%)
Gene names: DPP8, DPRP1, MSTP097, MSTP135, MSTP141
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P61
Unit cell:
a: 149.505Å b: 149.505Å c: 269.331Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.193 0.228
Expression system: Spodoptera frugiperda