7aym

X-ray diffraction
2.12Å resolution

Structure of DDR2 Kinase domain in complex with IBZ3

Released:
Source organism: Homo sapiens
Entry authors: Nawrotek A, Talagas A, Vuillard LM, Miallau L

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Discoidin domain-containing receptor 2; Epithelial discoidin domain-containing receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 337 amino acids
Theoretical weight: 38.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16832 (Residues: 561-669, 682-825, 830-846, 848-849; Coverage: 33%)
  • Canonical: Q08345 (Residues: 605-607, 717-737, 882-885, 903-903, 906-913; Coverage: 4%)
Gene names: CAK, DDR1, DDR2, EDDR1, NEP, NTRK4, NTRKR3, PTK3A, RTK6, TKT, TRKE, TYRO10
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P212121
Unit cell:
a: 41.75Å b: 85.355Å c: 89.541Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.236 0.289
Expression system: Spodoptera frugiperda