› 7aw6

X-ray diffraction
1.95Å resolution

The extracellular region of CD33 with bound sialoside analogue P22

Released:
DOI: 10.2210/pdb7aw6/pdb
PDB 7aw6 coloured by chain and viewed from the front.
PDB 7aw6 coloured by chain and viewed from the side.
PDB 7aw6 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Bradshaw WJ, Katis VL, Thompson AP, Arrowsmith CH, Edwards AM, von Delft F, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myeloid cell surface antigen CD33 Chains: A, B
Molecule details ›
Chains: A, B
Length: 252 amino acids
Theoretical weight: 27.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20138 (Residues: 21-232; Coverage: 61%)
  • Best match: P20138-3 (Residues: 12-105)
Gene names: CD33, SIGLEC3
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand NAG 9 x NAG
Ligand FVP 2 x FVP
Ligand PO4 1 x PO4
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 59.641Å b: 103.23Å c: 84.495Å
α: 90° β: 110.42° γ: 90°
R-values:
R R work R free
0.196 0.194 0.246
Expression system: Homo sapiens

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