X-ray diffraction
1.48Å resolution

Crystal Structure of the first bromodomain of BRD4 in complex with a BzD ligand

Source organism: Homo sapiens
Entry authors: Picaud S, Hassel-Hart S, Tobias K, Spencer J, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Filippakopoulos P

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 37.265Å b: 44.706Å c: 78.742Å
α: 90° β: 90° γ: 90°
R R work R free
0.167 0.166 0.19
Expression system: Escherichia coli BL21(DE3)