Function and Biology Details
Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase M2, peptidyl-dipeptidase A
- Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
- Spike glycoprotein S1, N-terminal domain, betacoronavirus-like
- Coronavirus spike glycoprotein S1, C-terminal
- Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
- Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2
- Spike glycoprotein, N-terminal domain superfamily
- Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144194 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Processed angiotensin-converting enzyme 2
Molecule details ›
Chain: D
Length: 654 amino acids
Theoretical weight: 75.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Angiotensin-converting enzyme
Length: 654 amino acids
Theoretical weight: 75.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q9BYF1 (Residues: 19-613; Coverage: 76%)
Sequence domains: Angiotensin-converting enzyme
Spike protein S1
Molecule details ›
Chain: A
Length: 716 amino acids
Theoretical weight: 79.81 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 716 amino acids
Theoretical weight: 79.81 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
- Canonical: P0DTC2 (Residues: 1-685; Coverage: 53%)
Sequence domains:
